7T0D
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k
Summary for 7T0D
Entry DOI | 10.2210/pdb7t0d/pdb |
Related | 7T08 7T09 7T0A 7T0B 7T0C 7T0E |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, 1,2-ETHANEDIOL, ... (9 entities in total) |
Functional Keywords | inhibitor, protein prenylyltransferase, antifungal, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Cryptococcus neoformans var. grubii H99 More |
Total number of polymer chains | 2 |
Total formula weight | 103974.00 |
Authors | Wang, Y.,Shi, Y.,Beese, L.S. (deposition date: 2021-11-29, release date: 2022-11-09, Last modification date: 2023-10-18) |
Primary citation | Wang, Y.,Xu, F.,Nichols, C.B.,Shi, Y.,Hellinga, H.W.,Alspaugh, J.A.,Distefano, M.D.,Beese, L.S. Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65:13753-13770, 2022 Cited by PubMed: 36218371DOI: 10.1021/acs.jmedchem.2c00902 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.906 Å) |
Structure validation
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