7T0C

Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e

7T0C の概要

• エントリーDOI: 10.2210/pdb7t0c/pdb
• 関連するPDBエントリー: 7T08 7T09 7T0A 7T0B 7T0D 7T0E
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, 1,2-ETHANEDIOL, ... (9 entities in total)
• 機能のキーワード: inhibitor, protein prenylyltransferase, antifungal, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Cryptococcus neoformans var. grubii H99; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102848.51

構造登録者

Wang, Y.,Shi, Y.,Beese, L.S. (登録日: 2021-11-29, 公開日: 2022-11-09, 最終更新日: 2023-10-18)

• 主引用文献: Wang, Y.,Xu, F.,Nichols, C.B.,Shi, Y.,Hellinga, H.W.,Alspaugh, J.A.,Distefano, M.D.,Beese, L.S.; Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.; J.Med.Chem., 65:13753-13770, 2022; PubMed: 36218371; DOI: 10.1021/acs.jmedchem.2c00902

実験手法

X-RAY DIFFRACTION (1.903 Å)