7T0C

Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	polymer	349	40913.2	1	UniProt (J9VSJ6) Pfam (PF01239)	Cryptococcus neoformans var. grubii H99	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha,variant
2	B (B)	Protein farnesyltransferase subunit beta	polymer	520	56806.9	1	UniProt (T2BPA1) Pfam (PF00432)	Cryptococcus neoformans var. grubii H99	FTase-beta
3	AA, AB, BA, BB, C... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	54	Chemie (EDO)
4	U (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	V (B)	(5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one	non-polymer		521.0	1	Chemie (XN4)
6	LA, MA, VA (B)	(2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid	non-polymer		237.3	3	Chemie (3FX)
7	JB (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
8	KB (B)	FARNESYL DIPHOSPHATE	non-polymer		382.3	1	Chemie (FPP)
9	LB, MB (A, B)	water	water		18.0	554	Chemie (HOH)

Sequence modifications

A: 1 - 335 (UniProt: J9VSJ6)

PDB	External Database	Details
Met -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Leu 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	97720.1
Non-Polymers*	Number of molecules	61
	Total formula weight	5128.4
All*	Total formula weight	102848.5

*Water molecules are not included.