7SZW

JAK2 JH2 in complex with JAK249

Summary for 7SZW

Entry DOI	10.2210/pdb7szw/pdb
Descriptor	Tyrosine-protein kinase JAK2, 4-(4-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}phenyl)pyridine-2-carboxylic acid (3 entities in total)
Functional Keywords	pseudokinase domain, inhibitor, complex, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33615.44
Authors	Krimmer, S.G.,Liosi, M.E.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2021-11-29, release date: 2024-09-04)
Primary citation	Liosi, M.E.,Ippolito, J.A.,Henry, S.P.,Krimmer, S.G.,Newton, A.S.,Cutrona, K.J.,Olivarez, R.A.,Mohanty, J.,Schlessinger, J.,Jorgensen, W.L. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. J.Med.Chem., 65:8380-8400, 2022 Cited by PubMed: 35653642 DOI: 10.1021/acs.jmedchem.2c00283 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.90646266564 Å)

Structure validation