7SZW
JAK2 JH2 in complex with JAK249
Summary for 7SZW
Entry DOI | 10.2210/pdb7szw/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 4-(4-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}phenyl)pyridine-2-carboxylic acid (3 entities in total) |
Functional Keywords | pseudokinase domain, inhibitor, complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33615.44 |
Authors | Krimmer, S.G.,Liosi, M.E.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2021-11-29, release date: 2024-09-04) |
Primary citation | Liosi, M.E.,Ippolito, J.A.,Henry, S.P.,Krimmer, S.G.,Newton, A.S.,Cutrona, K.J.,Olivarez, R.A.,Mohanty, J.,Schlessinger, J.,Jorgensen, W.L. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. J.Med.Chem., 65:8380-8400, 2022 Cited by PubMed: 35653642DOI: 10.1021/acs.jmedchem.2c00283 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.90646266564 Å) |
Structure validation
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