7SZQ

Human P300 complexed with an azaindazole inhibitor

7SZQ の概要

• エントリーDOI: 10.2210/pdb7szq/pdb
• 分子名称: Histone acetyltransferase p300, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide (3 entities in total)
• 機能のキーワード: histone acetyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45447.07

構造登録者

Shewchuk, L.M.,Reid, R.A. (登録日: 2021-11-29, 公開日: 2022-11-09, 最終更新日: 2023-10-18)

• 主引用文献: Tian, X.,Suarez, D.,Thomson, D.,Li, W.,King, E.A.,LaFrance, L.,Boehm, J.,Barton, L.,Di Marco, C.,Martyr, C.,Thalji, R.,Medina, J.,Knight, S.,Heerding, D.,Gao, E.,Nartey, E.,Cecconie, T.,Nixon, C.,Zhang, G.,Berrodin, T.J.,Phelps, C.,Patel, A.,Bai, X.,Lind, K.,Prabhu, N.,Messer, J.,Zhu, Z.,Shewchuk, L.,Reid, R.,Graves, A.P.,McHugh, C.,Mangatt, B.; Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.; J.Med.Chem., 65:14391-14408, 2022; PubMed: 36302181; DOI: 10.1021/acs.jmedchem.2c00670

実験手法

X-RAY DIFFRACTION (2.8 Å)