7SYF

Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

Summary for 7SYF

Entry DOI	10.2210/pdb7syf/pdb
EMDB information	25524 25525 25526
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera (1 entity in total)
Functional Keywords	guanine nucleotide exchange factor, metastasis, plasma membrane, rho gtpase signalling, oncoprotein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	191462.98
Authors	Lupton, C.J.,Bayly-Jones, C.,Ellisdon, A.M. (deposition date: 2021-11-24, release date: 2022-07-27, Last modification date: 2024-02-28)
Primary citation	Chang, Y.G.,Lupton, C.J.,Bayly-Jones, C.,Keen, A.C.,D'Andrea, L.,Lucato, C.M.,Steele, J.R.,Venugopal, H.,Schittenhelm, R.B.,Whisstock, J.C.,Halls, M.L.,Ellisdon, A.M. Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29:767-773, 2022 Cited by PubMed: 35864164 DOI: 10.1038/s41594-022-00804-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation