7SV2

Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin

7SV2 の概要

• エントリーDOI: 10.2210/pdb7sv2/pdb
• 分子名称: Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl [(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetate, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, binding properties, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 225745.48

構造登録者

Hsu, M.,Johnson, E.F. (登録日: 2021-11-18, 公開日: 2022-05-18, 最終更新日: 2023-10-18)

• 主引用文献: Hsu, M.H.,Johnson, E.F.; Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5.; J.Biol.Chem., 298:101909-101909, 2022; PubMed: 35398097; DOI: 10.1016/j.jbc.2022.101909

実験手法

X-RAY DIFFRACTION (2.46 Å)