7SU0

Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4

7SU0 の概要

• エントリーDOI: 10.2210/pdb7su0/pdb
• 分子名称: Cytotoxic T-lymphocyte protein 4, Fab heavy chain, Fab light chain, ... (7 entities in total)
• 機能のキーワード: immunoglobulin, checkpoint, antibody, complex, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 124623.12

構造登録者

Lee, P.S.,Chau, B.,Strop, P. (登録日: 2021-11-15, 公開日: 2022-03-02, 最終更新日: 2023-10-18)

• 主引用文献: Lee, P.S.,MacDonald, K.G.,Massi, E.,Chew, P.V.,Bee, C.,Perkins, P.,Chau, B.,Thudium, K.,Lohre, J.,Nandi, P.,Deyanova, E.G.,Barman, I.,Gudmundsson, O.,Dollinger, G.,Sproul, T.,Engelhardt, J.J.,Strop, P.,Rajpal, A.; Improved therapeutic index of an acidic pH-selective antibody.; Mabs, 14:2024642-2024642, 2022; PubMed: 35192429; DOI: 10.1080/19420862.2021.2024642

実験手法

X-RAY DIFFRACTION (2.41 Å)