7SSM
Crystal structure of human STING R232 in complex with compound 11
Summary for 7SSM
Entry DOI | 10.2210/pdb7ssm/pdb |
Descriptor | Stimulator of interferon genes protein, 2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid (3 entities in total) |
Functional Keywords | receptor, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24390.25 |
Authors | Sack, J.S.,Critton, D.A. (deposition date: 2021-11-11, release date: 2022-02-09, Last modification date: 2023-10-18) |
Primary citation | Cherney, E.C.,Zhang, L.,Lo, J.,Huynh, T.,Wei, D.,Ahuja, V.,Quesnelle, C.,Schieven, G.L.,Futran, A.,Locke, G.A.,Lin, Z.,Monereau, L.,Chaudhry, C.,Blum, J.,Li, S.,Fereshteh, M.,Li-Wang, B.,Gangwar, S.,Pan, C.,Chong, C.,Zhu, X.,Posy, S.L.,Sack, J.S.,Zhang, P.,Ruzanov, M.,Harner, M.,Akhtar, F.,Schroeder, G.M.,Vite, G.,Fink, B. Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization. J.Med.Chem., 65:3518-3538, 2022 Cited by PubMed: 35108011DOI: 10.1021/acs.jmedchem.1c01986 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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