7SSM

Crystal structure of human STING R232 in complex with compound 11

7SSM の概要

• エントリーDOI: 10.2210/pdb7ssm/pdb
• 分子名称: Stimulator of interferon genes protein, 2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid (3 entities in total)
• 機能のキーワード: receptor, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24390.25

構造登録者

Sack, J.S.,Critton, D.A. (登録日: 2021-11-11, 公開日: 2022-02-09, 最終更新日: 2023-10-18)

• 主引用文献: Cherney, E.C.,Zhang, L.,Lo, J.,Huynh, T.,Wei, D.,Ahuja, V.,Quesnelle, C.,Schieven, G.L.,Futran, A.,Locke, G.A.,Lin, Z.,Monereau, L.,Chaudhry, C.,Blum, J.,Li, S.,Fereshteh, M.,Li-Wang, B.,Gangwar, S.,Pan, C.,Chong, C.,Zhu, X.,Posy, S.L.,Sack, J.S.,Zhang, P.,Ruzanov, M.,Harner, M.,Akhtar, F.,Schroeder, G.M.,Vite, G.,Fink, B.; Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.; J.Med.Chem., 65:3518-3538, 2022; PubMed: 35108011; DOI: 10.1021/acs.jmedchem.1c01986

実験手法

X-RAY DIFFRACTION (1.96 Å)