7SSE
Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70
Summary for 7SSE
Entry DOI | 10.2210/pdb7sse/pdb |
Descriptor | DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine (3 entities in total) |
Functional Keywords | wd-repeat, wdr, dcaf1, sgc, structural genomics, structural genomics consortium, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71543.32 |
Authors | Kimani, S.,Owen, J.,Li, A.,Dong, A.,Li, Y.,Hutchinson, A.,Seitova, A.,Shahani, V.M.,Schapira, M.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2021-11-10, release date: 2021-12-15, Last modification date: 2023-11-22) |
Primary citation | Kimani, S.W.,Owen, J.,Green, S.R.,Li, F.,Li, Y.,Dong, A.,Brown, P.J.,Ackloo, S.,Kuter, D.,Yang, C.,MacAskill, M.,MacKinnon, S.S.,Arrowsmith, C.H.,Schapira, M.,Shahani, V.,Halabelian, L. Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. J.Chem.Inf.Model., 63:4070-4078, 2023 Cited by PubMed: 37350740DOI: 10.1021/acs.jcim.3c00082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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