7SSB

Co-structure of PKG1 regulatory domain with compound 33

7SSB の概要

• エントリーDOI: 10.2210/pdb7ssb/pdb
• 分子名称: cGMP-dependent protein kinase 1, 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid (3 entities in total)
• 機能のキーワード: binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent, protein kinase type ii, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31012.27

構造登録者

Fischmann, T.O. (登録日: 2021-11-10, 公開日: 2022-08-24, 最終更新日: 2023-10-18)

• 主引用文献: Mak, V.W.,Patel, A.M.,Yen, R.,Hanisak, J.,Lim, Y.H.,Bao, J.,Zheng, R.,Seganish, W.M.,Yu, Y.,Healy, D.R.,Ogawa, A.,Ren, Z.,Soriano, A.,Ermakov, G.P.,Beaumont, M.,Metwally, E.,Cheng, A.C.,Verras, A.,Fischmann, T.,Zebisch, M.,Silvestre, H.L.,McEwan, P.A.,Barker, J.,Rearden, P.,Greshock, T.J.; Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1 alpha.; J.Med.Chem., 65:10318-10340, 2022; PubMed: 35878399; DOI: 10.1021/acs.jmedchem.1c02109

実験手法

X-RAY DIFFRACTION (1.4 Å)