7SRV

Metal dependent activation of Plasmodium falciparum M17 aminopeptidase (inactive form), spacegroup P22121

Summary for 7SRV

• Entry DOI: 10.2210/pdb7srv/pdb
• Descriptor: M17 leucyl aminopeptidase, ZINC ION, CARBONATE ION, ... (9 entities in total)
• Functional Keywords: malaria, enzyme, metallo aminopeptidase, peptide binding protein
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 6
• Total formula weight: 354219.36

Authors

Webb, C.T.,McGowan, S. (deposition date: 2021-11-08, release date: 2022-06-29, Last modification date: 2023-10-18)

• Primary citation: Webb, C.T.,Yang, W.,Riley, B.T.,Hayes, B.K.,Sivaraman, K.K.,Malcolm, T.R.,Harrop, S.,Atkinson, S.C.,Kass, I.,Buckle, A.M.,Drinkwater, N.,McGowan, S.; A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.; J.Biol.Chem., 298:102119-102119, 2022; PubMed: 35691342; DOI: 10.1016/j.jbc.2022.102119

Experimental method

X-RAY DIFFRACTION (2.03 Å)