7SR6

Human Endogenous Retrovirus (HERV-K) reverse transcriptase ternary complex with dsDNA template Primer and dNTP

Summary for 7SR6

• Entry DOI: 10.2210/pdb7sr6/pdb
• Descriptor: Polymerase, THYMIDINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... (12 entities in total)
• Functional Keywords: reverse transcriptase rt dctp dttp dsdna template primer, replication
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 313828.27

Authors

Baldwin, E.T.,Nichols, C. (deposition date: 2021-11-08, release date: 2022-07-20)

• Primary citation: Baldwin, E.T.,Gotte, M.,Tchesnokov, E.P.,Arnold, E.,Hagel, M.,Nichols, C.,Dossang, P.,Lamers, M.,Wan, P.,Steinbacher, S.,Romero, D.L.; Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.; Proc.Natl.Acad.Sci.USA, 119:e2200260119-e2200260119, 2022; PubMed: 35771941; DOI: 10.1073/pnas.2200260119

Experimental method

X-RAY DIFFRACTION (2.62 Å)