7SQA
PPAR gamma LBD bound to SR10221 and SMRT corepressor motif
Summary for 7SQA
Entry DOI | 10.2210/pdb7sqa/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 2, (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid, ... (4 entities in total) |
Functional Keywords | inverse agonist, nuclear receptor, ligand binding domain, corepressor, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 72923.26 |
Authors | Frkic, R.L.,Pederick, J.L.,Bruning, J.B. (deposition date: 2021-11-05, release date: 2023-05-10, Last modification date: 2023-10-25) |
Primary citation | Frkic, R.L.,Pederick, J.L.,Horsfall, A.J.,Jovcevski, B.,Crame, E.E.,Kowalczyk, W.,Pukala, T.L.,Chang, M.R.,Zheng, J.,Blayo, A.L.,Abell, A.D.,Kamenecka, T.M.,Harbort, J.S.,Harmer, J.R.,Griffin, P.R.,Bruning, J.B. PPAR gamma Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. Acs Chem.Biol., 18:1115-1123, 2023 Cited by PubMed: 37146157DOI: 10.1021/acschembio.2c00917 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.499 Å) |
Structure validation
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