7SQA
PPAR gamma LBD bound to SR10221 and SMRT corepressor motif
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 290 | 33300.5 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
2 | C, D | Nuclear receptor corepressor 2 | polymer | 22 | 2600.0 | 2 | UniProt (Q9Y618) In PDB | Homo sapiens | N-CoR2,CTG repeat protein 26,SMAP270,Silencing mediator of retinoic acid and thyroid hormone receptor,SMRT,T3 receptor-associating factor,TRAC,Thyroid-,retinoic-acid-receptor-associated corepressor |
3 | A, B | (2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid | non-polymer | 561.1 | 2 | Chemie (A8R) | |||
4 | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 203 - 477 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Met 188 | - | initiating methionine |
Ala 189 | - | expression tag |
His 190 | - | expression tag |
His 191 | - | expression tag |
His 192 | - | expression tag |
His 193 | - | expression tag |
His 194 | - | expression tag |
His 195 | - | expression tag |
Val 196 | - | expression tag |
Asp 197 | - | expression tag |
Asp 198 | - | expression tag |
Asp 199 | - | expression tag |
Asp 200 | - | expression tag |
Lys 201 | - | expression tag |
Met 202 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 71801.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1122.2 | |
All* | Total formula weight | 72923.3 |