7SQA

PPAR gamma LBD bound to SR10221 and SMRT corepressor motif

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor gamma	polymer	290	33300.5	2	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	C, D (C, D)	Nuclear receptor corepressor 2	polymer	22	2600.0	2	UniProt (Q9Y618)	Homo sapiens	N-CoR2,CTG repeat protein 26,SMAP270,Silencing mediator of retinoic acid and thyroid hormone receptor,SMRT,T3 receptor-associating factor,TRAC,Thyroid-,retinoic-acid-receptor-associated corepressor
3	E, F (A, B)	(2S)-2-{5-[(5-{[(1S)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid	non-polymer		561.1	2	Chemie (A8R)
4	G, H, I, J (A, B, C, D)	water	water		18.0	191	Chemie (HOH)

Sequence modifications

A, B: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 188	-	initiating methionine
Ala 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
Val 196	-	expression tag
Asp 197	-	expression tag
Asp 198	-	expression tag
Asp 199	-	expression tag
Asp 200	-	expression tag
Lys 201	-	expression tag
Met 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	71801.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1122.2
All*	Total formula weight	72923.3

*Water molecules are not included.