7SPS

Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47

Summary for 7SPS

Entry DOI	10.2210/pdb7sps/pdb
Descriptor	Solute carrier family 2, facilitated glucose transporter member 3, methyl N-[(2-{4-[4-(5-fluoro-2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}phenyl)methyl]-beta-alaninate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywords	mfs, hexose transporter, inhibitor, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	116637.68
Authors	Wang, N.,Jiang, X.,Yan, N. (deposition date: 2021-11-03, release date: 2022-05-18, Last modification date: 2023-10-18)
Primary citation	Wang, N.,Zhang, S.,Yuan, Y.,Xu, H.,Defossa, E.,Matter, H.,Besenius, M.,Derdau, V.,Dreyer, M.,Halland, N.,He, K.H.,Petry, S.,Podeschwa, M.,Tennagels, N.,Jiang, X.,Yan, N. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nat Commun, 13:2632-2632, 2022 Cited by PubMed: 35552392 DOI: 10.1038/s41467-022-30326-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation