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7SPS

Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47

7SPS の概要
エントリーDOI10.2210/pdb7sps/pdb
分子名称Solute carrier family 2, facilitated glucose transporter member 3, methyl N-[(2-{4-[4-(5-fluoro-2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}phenyl)methyl]-beta-alaninate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
機能のキーワードmfs, hexose transporter, inhibitor, transport protein-inhibitor complex, transport protein/inhibitor
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数2
化学式量合計116637.68
構造登録者
Wang, N.,Jiang, X.,Yan, N. (登録日: 2021-11-03, 公開日: 2022-05-18, 最終更新日: 2023-10-18)
主引用文献Wang, N.,Zhang, S.,Yuan, Y.,Xu, H.,Defossa, E.,Matter, H.,Besenius, M.,Derdau, V.,Dreyer, M.,Halland, N.,He, K.H.,Petry, S.,Podeschwa, M.,Tennagels, N.,Jiang, X.,Yan, N.
Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
Nat Commun, 13:2632-2632, 2022
Cited by
PubMed: 35552392
DOI: 10.1038/s41467-022-30326-3
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.3 Å)
構造検証レポート
Validation report summary of 7sps
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-06-12に公開中

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