7SO1
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ564)
Summary for 7SO1
Entry DOI | 10.2210/pdb7so1/pdb |
Related | 7SNP 7SNZ |
Descriptor | Reverse transcriptase p66, p51 RT, 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino}-6-[3-(morpholin-4-yl)propoxy]-1,3,5-triazin-2-yl)amino]benzonitrile (3 entities in total) |
Functional Keywords | polymerase, transferase, hydrolase, rnaseh, transferase-viral protein complex, transferase/viral protein |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114539.32 |
Authors | Frey, K.M.,Anderson, K.S. (deposition date: 2021-10-28, release date: 2022-03-16, Last modification date: 2023-10-18) |
Primary citation | Frey, K.M.,Bertoletti, N.,Chan, A.H.,Ippolito, J.A.,Bollini, M.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9:805187-805187, 2022 Cited by PubMed: 35237658DOI: 10.3389/fmolb.2022.805187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.727 Å) |
Structure validation
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