7SNZ

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)amino)-5,7-dimethylindolizine-2-carbonitrile (JLJ604)

Summary for 7SNZ

• Entry DOI: 10.2210/pdb7snz/pdb
• Related: 7SNP
• Descriptor: Reverse transcriptase p66, p51 RT, (4R)-6-{[2-(4-cyanoanilino)pyrimidin-4-yl]amino}-5,7-dimethylindolizine-2-carbonitrile, ... (7 entities in total)
• Functional Keywords: polymerase, transferase, hydrolase, rnaseh, transferase-viral protein complex, transferase/viral protein
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Total number of polymer chains: 2
• Total formula weight: 114785.64

Authors

Frey, K.M.,Anderson, K.S. (deposition date: 2021-10-28, release date: 2022-03-16, Last modification date: 2023-10-18)

• Primary citation: Frey, K.M.,Bertoletti, N.,Chan, A.H.,Ippolito, J.A.,Bollini, M.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S.; Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase.; Front Mol Biosci, 9:805187-805187, 2022; PubMed: 35237658; DOI: 10.3389/fmolb.2022.805187

Experimental method

X-RAY DIFFRACTION (2.368 Å)