7SN8

Cryo-EM structure of Drosophila Integrator cleavage module (IntS4-IntS9-IntS11) in complex with IP6

Summary for 7SN8

• Entry DOI: 10.2210/pdb7sn8/pdb
• EMDB information: 25214
• Descriptor: Integrator complex subunit 4, Integrator complex subunit 11, Integrator complex subunit 9, ... (5 entities in total)
• Functional Keywords: integrator, inositol hexakisphosphate, nuclease
• Biological source: Drosophila melanogaster (fruit fly); More
• Total number of polymer chains: 3
• Total formula weight: 256555.18

Authors

Lin, M.,Tong, L. (deposition date: 2021-10-27, release date: 2022-10-12, Last modification date: 2024-06-05)

• Primary citation: Lin, M.H.,Jensen, M.K.,Elrod, N.D.,Huang, K.L.,Welle, K.A.,Wagner, E.J.,Tong, L.; Inositol hexakisphosphate is required for Integrator function.; Nat Commun, 13:5742-5742, 2022; PubMed: 36180473; DOI: 10.1038/s41467-022-33506-3

Experimental method

ELECTRON MICROSCOPY (2.74 Å)