7SKR
BtSCoV-Rf1.2004 Papain-Like protease bound to the non-covalent inhibitor 37
Summary for 7SKR
Entry DOI | 10.2210/pdb7skr/pdb |
Related | 7SKQ |
Descriptor | 3C-like proteinase, N-[(2-methoxypyridin-4-yl)methyl]-2-[(1R)-1-(naphthalen-1-yl)ethyl]-2-azaspiro[3.3]heptane-6-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | papain-like protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Bat SARS CoV Rf1/2004 |
Total number of polymer chains | 1 |
Total formula weight | 36500.12 |
Authors | Durie, I.,Shepard, J.,Freitas, B.,O'Boyle, B.,Enos, S.,Pegan, S.D. (deposition date: 2021-10-21, release date: 2022-03-02, Last modification date: 2023-11-15) |
Primary citation | Freitas, B.T.,Ahiadorme, D.A.,Bagul, R.S.,Durie, I.A.,Ghosh, S.,Hill, J.,Kramer, N.E.,Murray, J.,O'Boyle, B.M.,Onobun, E.,Pirrone, M.G.,Shepard, J.D.,Enos, S.,Subedi, Y.P.,Upadhyaya, K.,Tripp, R.A.,Cummings, B.S.,Crich, D.,Pegan, S.D. Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses. Acs Infect Dis., 8:596-611, 2022 Cited by PubMed: 35199517DOI: 10.1021/acsinfecdis.1c00631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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