7SKR

BtSCoV-Rf1.2004 Papain-Like protease bound to the non-covalent inhibitor 37

Summary for 7SKR

• Entry DOI: 10.2210/pdb7skr/pdb
• Related: 7SKQ
• Descriptor: 3C-like proteinase, N-[(2-methoxypyridin-4-yl)methyl]-2-[(1R)-1-(naphthalen-1-yl)ethyl]-2-azaspiro[3.3]heptane-6-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: papain-like protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Bat SARS CoV Rf1/2004
• Total number of polymer chains: 1
• Total formula weight: 36500.12

Authors

Durie, I.,Shepard, J.,Freitas, B.,O'Boyle, B.,Enos, S.,Pegan, S.D. (deposition date: 2021-10-21, release date: 2022-03-02, Last modification date: 2023-11-15)

• Primary citation: Freitas, B.T.,Ahiadorme, D.A.,Bagul, R.S.,Durie, I.A.,Ghosh, S.,Hill, J.,Kramer, N.E.,Murray, J.,O'Boyle, B.M.,Onobun, E.,Pirrone, M.G.,Shepard, J.D.,Enos, S.,Subedi, Y.P.,Upadhyaya, K.,Tripp, R.A.,Cummings, B.S.,Crich, D.,Pegan, S.D.; Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.; Acs Infect Dis., 8:596-611, 2022; PubMed: 35199517; DOI: 10.1021/acsinfecdis.1c00631

Experimental method

X-RAY DIFFRACTION (2.89 Å)