7SKQ

BtSCoV-Rf1.2004 Papain-Like protease bound to the non-covalent inhibitor GRL-0617

Summary for 7SKQ

• Entry DOI: 10.2210/pdb7skq/pdb
• Descriptor: 3C-like proteinase, ZINC ION, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ... (4 entities in total)
• Functional Keywords: papain-like protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Bat SARS CoV Rf1/2004
• Total number of polymer chains: 2
• Total formula weight: 72621.70

Authors

Freitas, B.,Durie, I.,Shepard, J.,O'Boyle, B.,Enos, S.,Pegan, S.D. (deposition date: 2021-10-21, release date: 2022-03-02, Last modification date: 2023-11-15)

• Primary citation: Freitas, B.T.,Ahiadorme, D.A.,Bagul, R.S.,Durie, I.A.,Ghosh, S.,Hill, J.,Kramer, N.E.,Murray, J.,O'Boyle, B.M.,Onobun, E.,Pirrone, M.G.,Shepard, J.D.,Enos, S.,Subedi, Y.P.,Upadhyaya, K.,Tripp, R.A.,Cummings, B.S.,Crich, D.,Pegan, S.D.; Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.; Acs Infect Dis., 8:596-611, 2022; PubMed: 35199517; DOI: 10.1021/acsinfecdis.1c00631

Experimental method

X-RAY DIFFRACTION (3.16 Å)