7SKK

pertussis toxin in complex with ADPR and Nicotinamide

7SKK の概要

• エントリーDOI: 10.2210/pdb7skk/pdb
• 関連するPDBエントリー: 7SKI
• 分子名称: Pertussis toxin subunit 1, NICOTINAMIDE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: toxin, adp-ribosyltransferase, transferase, whooping cough, inhibitor, pertussis, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Bordetella pertussis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 86107.49

構造登録者

Littler, D.R.,Beddoe, T.,Pulliainen, A.,Rossjohn, J. (登録日: 2021-10-21, 公開日: 2022-04-13, 最終更新日: 2023-10-18)

• 主引用文献: Sakari, M.,Tran, M.T.,Rossjohn, J.,Pulliainen, A.T.,Beddoe, T.,Littler, D.R.; Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.; J.Biol.Chem., 298:101892-101892, 2022; PubMed: 35378130; DOI: 10.1016/j.jbc.2022.101892

実験手法

X-RAY DIFFRACTION (1.65000771809 Å)