7SKK

pertussis toxin in complex with ADPR and Nicotinamide

Summary for 7SKK

Entry DOI	10.2210/pdb7skk/pdb
Related	7SKI
Descriptor	Pertussis toxin subunit 1, NICOTINAMIDE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
Functional Keywords	toxin, adp-ribosyltransferase, transferase, whooping cough, inhibitor, pertussis, transferase-inhibitor complex, transferase/inhibitor
Biological source	Bordetella pertussis
Total number of polymer chains	4
Total formula weight	86107.49
Authors	Littler, D.R.,Beddoe, T.,Pulliainen, A.,Rossjohn, J. (deposition date: 2021-10-21, release date: 2022-04-13, Last modification date: 2023-10-18)
Primary citation	Sakari, M.,Tran, M.T.,Rossjohn, J.,Pulliainen, A.T.,Beddoe, T.,Littler, D.R. Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298:101892-101892, 2022 Cited by PubMed: 35378130 DOI: 10.1016/j.jbc.2022.101892 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65000771809 Å)

Structure validation