7SJ3

Structure of CDK4-Cyclin D3 bound to abemaciclib

Summary for 7SJ3

• Entry DOI: 10.2210/pdb7sj3/pdb
• Descriptor: Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine, ... (4 entities in total)
• Functional Keywords: cdk, cyclin, kinase, inhibitor complex, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 64563.52

Authors

Hilgers, M.T.,Pelletier, L.A. (deposition date: 2021-10-15, release date: 2022-11-02, Last modification date: 2023-10-18)

• Primary citation: Hilgers, M.T.,Pelletier, L.A.; Structure of CDK4-Cyclin D3 bound to abemaciclib; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.51 Å)