7SJ2

N-acetylglucosamine-1-phosphotransferase (GNPT) alpha and beta subunits (GNPTAB) catalytic domain, from zebrafish, in complex with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) and magnesium

Summary for 7SJ2

• Entry DOI: 10.2210/pdb7sj2/pdb
• Descriptor: N-acetylglucosamine-1-phosphotransferase subunit alpha,N-acetylglucosamine-1-phosphotransferase (GNPT) alpha (GNPTAB) catalytic domain,N-acetylglucosamine-1-phosphotransferase subunit beta, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: gnpt, lysosome, mannose 6-phosphate, mucolipidosis, transferase
• Biological source: Danio rerio (Zebrafish, Brachydanio rerio); More
• Total number of polymer chains: 2
• Total formula weight: 122008.71

Authors

Gorelik, A.,Illes, K.,Nagar, B. (deposition date: 2021-10-15, release date: 2022-05-25, Last modification date: 2023-10-18)

• Primary citation: Gorelik, A.,Illes, K.,Bui, K.H.,Nagar, B.; Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.; Proc.Natl.Acad.Sci.USA, 119:e2203518119-e2203518119, 2022; PubMed: 35939698; DOI: 10.1073/pnas.2203518119

Experimental method

X-RAY DIFFRACTION (2.3 Å)