7SJ2

N-acetylglucosamine-1-phosphotransferase (GNPT) alpha and beta subunits (GNPTAB) catalytic domain, from zebrafish, in complex with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) and magnesium

7SJ2 の概要

• エントリーDOI: 10.2210/pdb7sj2/pdb
• 分子名称: N-acetylglucosamine-1-phosphotransferase subunit alpha,N-acetylglucosamine-1-phosphotransferase (GNPT) alpha (GNPTAB) catalytic domain,N-acetylglucosamine-1-phosphotransferase subunit beta, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: gnpt, lysosome, mannose 6-phosphate, mucolipidosis, transferase
• 由来する生物種: Danio rerio (Zebrafish, Brachydanio rerio); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122008.71

構造登録者

Gorelik, A.,Illes, K.,Nagar, B. (登録日: 2021-10-15, 公開日: 2022-05-25, 最終更新日: 2023-10-18)

• 主引用文献: Gorelik, A.,Illes, K.,Bui, K.H.,Nagar, B.; Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.; Proc.Natl.Acad.Sci.USA, 119:e2203518119-e2203518119, 2022; PubMed: 35939698; DOI: 10.1073/pnas.2203518119

実験手法

X-RAY DIFFRACTION (2.3 Å)