7SIL
Structure of positive allosteric modulator-bound active human calcium-sensing receptor
Summary for 7SIL
Entry DOI | 10.2210/pdb7sil/pdb |
EMDB information | 25143 |
Descriptor | Isoform 1 of Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | calcium-sensing receptor, cryo-em structure, allosteric modulation, activation mechanism, symmetry, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 206267.70 |
Authors | Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. (deposition date: 2021-10-14, release date: 2022-01-19) |
Primary citation | Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. Symmetric activation and modulation of the human calcium-sensing receptor. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34916296DOI: 10.1073/pnas.2115849118 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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