7SIL
Structure of positive allosteric modulator-bound active human calcium-sensing receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isoform 1 of Extracellular calcium-sensing receptor | polymer | 878 | 99299.5 | 2 | UniProt (P41180-1) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) UniProt (by SIFTS) (P41180) In PDB | Homo sapiens (Human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 2 | C, D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 4 | A, B | CYCLOMETHYLTRYPTOPHAN | non-polymer | 216.2 | 2 | Chemie (TCR) | |||
| 5 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 6 | B, A | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 7 | B, A | 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine | non-polymer | 303.8 | 2 | Chemie (9IG) | |||
| 8 | B, A | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) |
Sequence modifications
A, B: 1 - 870 (UniProt: P41180-1)
| PDB | External Database | Details |
|---|---|---|
| Asp 871 | - | expression tag |
| Tyr 872 | - | expression tag |
| Lys 873 | - | expression tag |
| Asp 874 | - | expression tag |
| Asp 875 | - | expression tag |
| Asp 876 | - | expression tag |
| Asp 877 | - | expression tag |
| Lys 878 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 198598.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 5971.2 | |
| All* | Total formula weight | 206267.7 |
