Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7SIL

Structure of positive allosteric modulator-bound active human calcium-sensing receptor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Isoform 1 of Extracellular calcium-sensing receptorpolymer87899299.52UniProt (P41180-1)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)
UniProt (by SIFTS) (P41180)
Homo sapiens (Human)CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2C, D, E, F
(C, D, E, F)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.44In PDB
GlyTouCan (G42666HT)
3G, H, I, U, V...
(A, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.26Chemie (NAG)
4J, X
(A, B)
CYCLOMETHYLTRYPTOPHANnon-polymer216.22Chemie (TCR)
5K, Y
(A, B)
PHOSPHATE IONnon-polymer95.02Chemie (PO4)
6AA, BA, CA, L, M...
(B, A)
CALCIUM IONnon-polymer40.18Chemie (CA)
7DA, P
(B, A)
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-aminenon-polymer303.82Chemie (9IG)
8EA, FA, GA, HA, Q...
(B, A)
CHOLESTEROLnon-polymer386.78Chemie (CLR)
Sequence modifications
A, B: 1 - 870 (UniProt: P41180-1)
PDBExternal DatabaseDetails
Asp 871-expression tag
Tyr 872-expression tag
Lys 873-expression tag
Asp 874-expression tag
Asp 875-expression tag
Asp 876-expression tag
Asp 877-expression tag
Lys 878-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight198598.9
BranchedNumber of molecules4
Total formula weight1697.6
Non-Polymers*Number of molecules28
Total formula weight5971.2
All*Total formula weight206267.7
*Water molecules are not included.

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon