7SII
Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)
Summary for 7SII
Entry DOI | 10.2210/pdb7sii/pdb |
EMDB information | 25142 |
Descriptor | Stimulator of interferon genes protein, 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, cGAMP (3 entities in total) |
Functional Keywords | sting, agonist, activate conformation, oligomer, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 160544.17 |
Authors | |
Primary citation | Lu, D.,Shang, G.,Li, J.,Lu, Y.,Bai, X.C.,Zhang, X. Activation of STING by targeting a pocket in the transmembrane domain. Nature, 604:557-562, 2022 Cited by PubMed: 35388221DOI: 10.1038/s41586-022-04559-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.45 Å) |
Structure validation
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