7SHV

Crystal structure of BRAF kinase domain bound to GDC0879

7SHV の概要

• エントリーDOI: 10.2210/pdb7shv/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71401.23

構造登録者

Kung, J.E.,Sudhamsu, J. (登録日: 2021-10-11, 公開日: 2022-10-26, 最終更新日: 2023-10-18)

• 主引用文献: Chen, X.,Wendorff, T.,Jao, C.,Kung, J.E.,Liau, N.P.D.,Wu, P.,Yu, C.,Oh, A.,Boenig, G.,Wallweber, H.,Everett, C.,Miu, A.,Brillantes, B.,Mortara, K.,Murray, J.,Koth, C.M.,Sudhamsu, J.; Clearing the Path to Rapid High-Quality Protein Purification; To Be Published,

実験手法

X-RAY DIFFRACTION (2.88 Å)