7SHT

Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant

7SHT の概要

• エントリーDOI: 10.2210/pdb7sht/pdb
• EMDBエントリー: 25136
• 分子名称: High affinity immunoglobulin epsilon receptor subunit alpha, Immunoglobulin heavy constant epsilon, clone_7 Variable fragment heavy chain, ... (8 entities in total)
• 機能のキーワード: ige, allergy, xolair, omalizumab, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 153771.69

構造登録者

Pennington, L.F.,Jardetzky, T.S. (登録日: 2021-10-11, 公開日: 2021-12-15)

• 主引用文献: Pennington, L.F.,Gasser, P.,Kleinboelting, S.,Zhang, C.,Skiniotis, G.,Eggel, A.,Jardetzky, T.S.; Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.; Nat Commun, 12:7069-7069, 2021; PubMed: 34862384; DOI: 10.1038/s41467-021-27397-z

実験手法

ELECTRON MICROSCOPY (7.29 Å)