7SHE

Cryo-EM structure of human GPR158

7SHE の概要

• エントリーDOI: 10.2210/pdb7she/pdb
• EMDBエントリー: 25125 25126
• 分子名称: G-protein coupled receptor 158, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, ... (4 entities in total)
• 機能のキーワード: receptor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 186640.82

構造登録者

Patil, D.N.,Singh, S.,Singh, A.K.,Martemyanov, K.A. (登録日: 2021-10-08, 公開日: 2021-12-01, 最終更新日: 2022-01-19)

• 主引用文献: Patil, D.N.,Singh, S.,Laboute, T.,Strutzenberg, T.S.,Qiu, X.,Wu, D.,Novick, S.J.,Robinson, C.V.,Griffin, P.R.,Hunt, J.F.,Izard, T.,Singh, A.K.,Martemyanov, K.A.; Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.; Science, 375:86-91, 2022; PubMed: 34793198; DOI: 10.1126/science.abl4732

実験手法

ELECTRON MICROSCOPY (3.4 Å)