7SH5
Crystal structure of CYP142A3 from Mycobacterium ulcerans bound to Cholest-4-en-3-one
Summary for 7SH5
Entry DOI | 10.2210/pdb7sh5/pdb |
Descriptor | Cytochrome P450 142A3, PROTOPORPHYRIN IX CONTAINING FE, (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, ... (6 entities in total) |
Functional Keywords | p450, heme, mono-oxygenase, lipid, catabolism, cholesterol, cholest-4-en-3-one, mycobacteria, tuberculosis, ulcerans, lipid binding protein, oxidoreductase |
Biological source | Mycobacterium ulcerans |
Total number of polymer chains | 4 |
Total formula weight | 186166.54 |
Authors | Doherty, D.Z.,Bell, S.G.,Bruning, J. (deposition date: 2021-10-08, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Ghith, A.,Doherty, D.Z.,Bruning, J.B.,Russell, R.A.,De Voss, J.J.,Bell, S.G. The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum. Acs Infect Dis., 8:1606-1617, 2022 Cited by PubMed: 35881654DOI: 10.1021/acsinfecdis.2c00215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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