7SGM

Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L

7SGM の概要

• エントリーDOI: 10.2210/pdb7sgm/pdb
• 分子名称: CD40 ligand, 5c8* Fab heavy chain, 5c8* Fab light chain, ... (8 entities in total)
• 機能のキーワード: fragment antigen binding (fab), noncanonical amino acid, 7-hydroxycoumarin, immune system, cytokine-immune system complex, cytokine/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 193887.32

構造登録者

Henderson, J.N.,Mills, J.H.,Simmons, C.R. (登録日: 2021-10-06, 公開日: 2022-02-02, 最終更新日: 2023-11-15)

• 主引用文献: Henderson, J.N.,Simmons, C.R.,Mills, J.H.; Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment.; J.Mol.Biol., 434:167455-167455, 2022; PubMed: 35033559; DOI: 10.1016/j.jmb.2022.167455

実験手法

X-RAY DIFFRACTION (2 Å)