7SGI
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Summary for 7SGI
Entry DOI | 10.2210/pdb7sgi/pdb |
Descriptor | Polyamine deacetylase HDAC10, 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, ZINC ION, ... (7 entities in total) |
Functional Keywords | histone deacetylase, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 75786.48 |
Authors | Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2021-10-05, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Steimbach, R.R.,Herbst-Gervasoni, C.J.,Lechner, S.,Stewart, T.M.,Klinke, G.,Ridinger, J.,Geraldy, M.N.E.,Tihanyi, G.,Foley, J.R.,Uhrig, U.,Kuster, B.,Poschet, G.,Casero Jr., R.A.,Medard, G.,Oehme, I.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144:18861-18875, 2022 Cited by PubMed: 36200994DOI: 10.1021/jacs.2c05030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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