7SEO

Crystal Structure of Caspase-3 with Peptide Inhibitor Ac-VDV(DAB)D-CHO

7SEO の概要

• エントリーDOI: 10.2210/pdb7seo/pdb
• 分子名称: Caspase-3 subunit p17, Caspase-3 subunit p12, ACE-VAL-ASP-VAL-DAB-ASP, ... (4 entities in total)
• 機能のキーワード: protease, inhibitor, covalent, apoptosis
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 56710.75

構造登録者

Fuller, J.L.,Finzel, B.C. (登録日: 2021-09-30, 公開日: 2022-01-05, 最終更新日: 2023-10-18)

• 主引用文献: Bresinsky, M.,Strasser, J.M.,Vallaster, B.,Liu, P.,McCue, W.M.,Fuller, J.,Hubmann, A.,Singh, G.,Nelson, K.M.,Cuellar, M.E.,Wilmot, C.M.,Finzel, B.C.,Ashe, K.H.,Walters, M.A.,Pockes, S.; Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.; Acs Pharmacol Transl Sci, 5:20-40, 2022; PubMed: 35059567; DOI: 10.1021/acsptsci.1c00251

実験手法

X-RAY DIFFRACTION (3.25 Å)