7SED

Crystal structure of human Fibrillarin in complex with compound 2a

Summary for 7SED

• Entry DOI: 10.2210/pdb7sed/pdb
• Descriptor: rRNA 2'-O-methyltransferase fibrillarin, N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidin-4-amine, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: methyltransferase, s-adenosyl methionine, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 26973.85

Authors

Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,von Itzstein, M.,Ve, T. (deposition date: 2021-09-30, release date: 2022-02-09, Last modification date: 2023-10-18)

• Primary citation: Shi, Y.,El-Deeb, I.M.,Masic, V.,Hartley-Tassell, L.,Maggioni, A.,Itzstein, M.V.,Ve, T.; Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.; Pharmaceuticals, 15:-, 2021; PubMed: 35056083; DOI: 10.3390/ph15010026

Experimental method

X-RAY DIFFRACTION (1.9 Å)