7S8H

Structure of Lassa virus glycoprotein bound to Fab 18.5C and Fab 36.1F

Summary for 7S8H

• Entry DOI: 10.2210/pdb7s8h/pdb
• Descriptor: Glycoprotein G1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: lassa virus, pre-fusion glycoprotein, fab fragment, antibody-mediated neutralization, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Lassa virus; More
• Total number of polymer chains: 6
• Total formula weight: 143631.14

Authors

Hastie, K.M.,Enriquez, A.S. (deposition date: 2021-09-17, release date: 2022-06-01, Last modification date: 2023-10-18)

• Primary citation: Enriquez, A.S.,Buck, T.K.,Li, H.,Norris, M.J.,Moon-Walker, A.,Zandonatti, M.A.,Harkins, S.S.,Robinson, J.E.,Branco, L.M.,Garry, R.F.,Saphire, E.O.,Hastie, K.M.; Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies.; Cell Rep, 39:110841-110841, 2022; PubMed: 35613585; DOI: 10.1016/j.celrep.2022.110841

Experimental method

X-RAY DIFFRACTION (2.7 Å)