7S6P

The crystal structure of human ISG15

Summary for 7S6P

• Entry DOI: 10.2210/pdb7s6p/pdb
• Descriptor: Ubiquitin-like protein ISG15 (2 entities in total)
• Functional Keywords: isg15, ubiquitin, signaling protein, center for structural genomics of infectious diseases, csgid
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 103828.58

Authors

Osipiuk, J.,Tesar, C.,Jedrzejczak, R.,Endres, M.,Wydorski, P.,Joachimiak, L.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2021-09-14, release date: 2021-09-22, Last modification date: 2023-10-25)

• Primary citation: Wydorski, P.M.,Osipiuk, J.,Lanham, B.T.,Tesar, C.,Endres, M.,Engle, E.,Jedrzejczak, R.,Mullapudi, V.,Michalska, K.,Fidelis, K.,Fushman, D.,Joachimiak, A.,Joachimiak, L.A.; Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.; Nat Commun, 14:2366-2366, 2023; PubMed: 37185902; DOI: 10.1038/s41467-023-38031-5

Experimental method

X-RAY DIFFRACTION (2.15 Å)