7S6H
Human PARP1 deltaV687-E688 bound to NAD+ analog EB-47 and to a DNA double strand break.
Summary for 7S6H
Entry DOI | 10.2210/pdb7s6h/pdb |
Related | 7S68 7S6M 7S81 |
Descriptor | DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), Poly [ADP-ribose] polymerase 1, ... (8 entities in total) |
Functional Keywords | parp, adp-ribose transferase, dna break detection, zinc finger, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 183808.42 |
Authors | Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2021-09-14, release date: 2022-06-29, Last modification date: 2023-10-18) |
Primary citation | Rouleau-Turcotte, E.,Krastev, D.B.,Pettitt, S.J.,Lord, C.J.,Pascal, J.M. Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82:2939-2951.e5, 2022 Cited by PubMed: 35793673DOI: 10.1016/j.molcel.2022.06.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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