7S6C

CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure

7S6C の概要

• エントリーDOI: 10.2210/pdb7s6c/pdb
• EMDBエントリー: 24862 24863 24864 24865 24866 24867 24868
• 分子名称: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Lsd14 Polyketide synthase fusion, Fab 1B2 heavy chain, Fab 1B2 light chain, ... (5 entities in total)
• 機能のキーワード: modular polyketide synthase, ketosynthase, ketoreductase, acyl carrier protein, biosynthetic protein
• 由来する生物種: Saccharopolyspora erythraea; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 801535.35

構造登録者

Bagde, S.R.,Kim, C.-Y.,Fromme, J.C. (登録日: 2021-09-13, 公開日: 2021-11-03, 最終更新日: 2021-11-17)

• 主引用文献: Bagde, S.R.,Mathews, I.I.,Fromme, J.C.,Kim, C.Y.; Modular polyketide synthase contains two reaction chambers that operate asynchronously.; Science, 374:723-729, 2021; PubMed: 34735234; DOI: 10.1126/science.abi8532

実験手法

ELECTRON MICROSCOPY (3.1 Å)