7S59

Crystal structure of the tick evasin EVA-P974 complexed to a chimera made of human chemokines CCL7 and CCL8

7S59 の概要

• エントリーDOI: 10.2210/pdb7s59/pdb
• 分子名称: Evasin P974, chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif chemokine 7, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inflammation, evasin, chemokine binder, evasin-chemokine complex, immune system
• 由来する生物種: Amblyomma cajennense (Cayenne tick, Acarus cajennensis); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 37409.14

構造登録者

Bhusal, R.P.,Devkota, S.R.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (登録日: 2021-09-10, 公開日: 2022-03-16, 最終更新日: 2023-10-18)

• 主引用文献: Bhusal, R.P.,Aryal, P.,Devkota, S.R.,Pokhrel, R.,Gunzburg, M.J.,Foster, S.R.,Lim, H.D.,Payne, R.J.,Wilce, M.C.J.,Stone, M.J.; Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 35217625; DOI: 10.1073/pnas.2122105119

実験手法

X-RAY DIFFRACTION (2.39 Å)