7S4G

Fab fragment bound to the Cter peptide of Ly6G6D

Summary for 7S4G

Entry DOI	10.2210/pdb7s4g/pdb
Descriptor	heavy chain Fab 1G4, light chain Fab 1G4, Lymphocyte antigen 6 complex locus protein G6d, ... (6 entities in total)
Functional Keywords	leukocyte antigen-6, signaling protein
Biological source	Homo sapiens More
Total number of polymer chains	12
Total formula weight	197392.36
Authors	Rouge, L.,Lupardus, P. (deposition date: 2021-09-08, release date: 2022-04-13, Last modification date: 2023-10-18)
Primary citation	Wang, P.,Sun, L.L.,Clark, R.,Hristopoulos, M.,Chiu, C.P.C.,Dillon, M.,Lin, W.,Lo, A.A.,Chalsani, S.,Das Thakur, M.,Zimmerman Savill, K.M.,Rouge, L.,Lupardus, P.,Piskol, R.,Husain, B.,Ellerman, D.,Shivva, V.,Leong, S.R.,Ovacik, M.,Totpal, K.,Wu, Y.,Spiess, C.,Lee, G.,Leipold, D.D.,Polson, A.G. Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer. Mol.Cancer Ther., 21:974-985, 2022 Cited by PubMed: 35364611 DOI: 10.1158/1535-7163.MCT-21-0599 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation