7S3V
Structure of HsKYNase_66, an evolved variant of human kynureninase with greatly increased activity towards kynurenine
Summary for 7S3V
Entry DOI | 10.2210/pdb7s3v/pdb |
Descriptor | Kynureninase (1 entity in total) |
Functional Keywords | kynurenine, tryptophan, cancer, directed-evolution, antitumor protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 106019.68 |
Authors | Burkholder, N.T.,Zhang, Y.J. (deposition date: 2021-09-08, release date: 2022-12-21, Last modification date: 2023-11-15) |
Primary citation | Blazeck, J.,Karamitros, C.S.,Ford, K.,Somody, C.,Qerqez, A.,Murray, K.,Burkholder, N.T.,Marshall, N.,Sivakumar, A.,Lu, W.C.,Tan, B.,Lamb, C.,Tanno, Y.,Siddiqui, M.Y.,Ashoura, N.,Coma, S.,Zhang, X.M.,McGovern, K.,Kumada, Y.,Zhang, Y.J.,Manfredi, M.,Johnson, K.A.,D'Arcy, S.,Stone, E.,Georgiou, G. Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme. Nat Catal, 5:952-967, 2022 Cited by PubMed: 36465553DOI: 10.1038/s41929-022-00856-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.249 Å) |
Structure validation
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