7S05

Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex

7S05 の概要

• エントリーDOI: 10.2210/pdb7s05/pdb
• EMDBエントリー: 24784
• 分子名称: N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: glcnac-1-phosphotransferase, lysosomal hydrolases, mannose 6-phosphate trafficking pathway, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 272680.01

構造登録者

Li, H.,Li, H. (登録日: 2021-08-30, 公開日: 2022-03-30, 最終更新日: 2022-04-27)

• 主引用文献: Li, H.,Lee, W.S.,Feng, X.,Bai, L.,Jennings, B.C.,Liu, L.,Doray, B.,Canfield, W.M.,Kornfeld, S.,Li, H.; Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.; Nat.Struct.Mol.Biol., 29:348-356, 2022; PubMed: 35332324; DOI: 10.1038/s41594-022-00748-0

実験手法

ELECTRON MICROSCOPY (3.1 Å)