7RYB

S. CEREVISIAE CYP51 Y140H/I471T - double mutant COMPLEXED WITH Voriconazole

Summary for 7RYB

• Entry DOI: 10.2210/pdb7ryb/pdb
• Related: 5HS1
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total)
• Functional Keywords: cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor
• Biological source: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 62813.93

Authors

Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (deposition date: 2021-08-24, release date: 2021-09-01, Last modification date: 2023-10-18)

• Primary citation: Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C.; Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase as a Surrogate.; J Fungi (Basel), 7:-, 2021; PubMed: 34829185; DOI: 10.3390/jof7110897

Experimental method

X-RAY DIFFRACTION (2.9 Å)