7RQE

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution

これはPDB形式変換不可エントリーです。

7RQE の概要

• エントリーDOI: 10.2210/pdb7rqe/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total)
• 機能のキーワード: chloramphenicol, linezolid, antibiotic, peptidyl-trna, 70s ribosome, inhibition of translation, uncompetitive inhibition, peptidyl transferase center, context-specificity of drug action, ribosome
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4432494.75

構造登録者

Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. (登録日: 2021-08-06, 公開日: 2022-01-26, 最終更新日: 2023-11-15)

• 主引用文献: Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S.; Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.; Nat.Struct.Mol.Biol., 29:152-161, 2022; PubMed: 35165455; DOI: 10.1038/s41594-022-00720-y

実験手法

X-RAY DIFFRACTION (2.4 Å)