7RQC

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution

これはPDB形式変換不可エントリーです。

7RQC の概要

• エントリーDOI: 10.2210/pdb7rqc/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total)
• 機能のキーワード: chloramphenicol; linezolid; antibiotic; peptidyl-trna; 70s ribosome; x-ray structure; inhibition of translation; uncompetitive inhibition; peptidyl transferase center; context-specificity of drug action, ribosome
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4432038.56

構造登録者

Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S. (登録日: 2021-08-06, 公開日: 2022-01-26, 最終更新日: 2023-11-15)

• 主引用文献: Syroegin, E.A.,Flemmich, L.,Klepacki, D.,Vazquez-Laslop, N.,Micura, R.,Polikanov, Y.S.; Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.; Nat.Struct.Mol.Biol., 29:152-161, 2022; PubMed: 35165455; DOI: 10.1038/s41594-022-00720-y

実験手法

X-RAY DIFFRACTION (2.5 Å)